A Novel Role for Escherichia Coli NDP Kinase in DNA Replication and Mutagenesis in Vivo

A Novel Role for Escherichia Coli NDP Kinase in DNA Replication and Mutagenesis in Vivo

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To maximize the efficiency and fidelity of DNA replication, multiple processes such as DNA synthesis, DNA repair and dNTP synthesis must work in concert. Over-initiation of DNA replication has been shown to lead to extensive DNA damage, potentially due to head to tail replication fork collisions that ultimately lead to replication fork collapse, growth stasis and/or cell death. Based on the assumption that suppressors of a lethal over-initiation phenotype should include mutations that affect the efficiency and/or regulation of DNA replication, we identified and characterized multiple suppressors involved in DNA replication. The suppressor mutations fell into two distinct categories: those that directly inhibit over-initiation of DNA replication and those that act independently of initiation, presumably by decreasing the rate of replication fork progression. Mutations that result in loss of nucleoside diphosphate kinase, Ndk, function fall into the latter category.TRANSLESION (TLS) DNA SYNTHESIS As discussed above, replication forks encounter a number of DNA lesions that require DNA repair and replication fork restart in order accurately duplicate the template DNA. But, there is a plethora ofanbsp;...


Title:A Novel Role for Escherichia Coli NDP Kinase in DNA Replication and Mutagenesis in Vivo
Author:
Publisher:ProQuest - 2008
ISBN-13:

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